Pregnant fair sex who take ibuprofen in the first 24 workweek of pregnancy risk harm the future birth rate of their unborn daughters , according to a study published inHuman Reproduction .
The team found that vulnerability to ibuprofen during the other stage of pregnancy resulted in a large red ink of germ cells , the cell that go into making the gametes ( the cells that fuse during fertilization ) in organisms that reproduce sexually . Analyzing ovarian tissue , they found many of the germ cells either stopped growing or completely break .
Ibuprofen is a nonsteroidal anti - incitive medication used to help treat aches , febrility , and migraines . The researchers note that taking the drug for just a twosome of Clarence Shepard Day Jr. could still cause serious fertility issue . This is significant because around 30 percent of women have been figure to use ibuprofen during the first three months of gestation .
The study involve 185 fetus from pregnancy terminations that were 7 to 12 weeks old . The team cultured ovarian tissue in a research lab and quiz the rake from the umbilical cord of the fetuses to watch whether photo to isobutylphenyl propionic acid caused any impairment . This revealed that ibuprofen crosses the placental roadblock .
" The concentration that we determine in the umbilical cords of fetuses from mothers who ingested 800 mg ( four pill of 200 mg ) two to four hour before surgery is similar to the concentration that can be found in adult ’s blood for the same treatment , " enounce Dr Severine Mazaud - Guittot , a researcher at Inserm , France , in astatement .
They find fetal tissue exposed to Nuprin for seven days had about half the number of ovarian germ cells .
“ We found there were fewer cell growing and dividing , more cubicle dying and a striking deprivation of germ cell number , regardless of the gestational historic period of the fetus , ” said Dr Mazaud - Guittot . " There were significant effects after seven mean solar day of exposure to 10 μM of Nuprin , and we saw cell death as early as after two days of discussion . Five Clarence Shepard Day Jr. after unsay Motrin , these harmful effect of ibuprofen were not in full countermand . "
Limitations of the subject field admit the tests being transport out in a laboratory instead of a living cleaning woman ’s torso and the short duration of cultivated cells meaning they could n’t study the long - term effects of the fertility of the reproductive function of the daughters .
This is n’t the first time painkillers have been associate with health risks for pregnant women though . Aprevious studyshowed that mothers who take acetaminophen risk exhibit their tyke to language developing problems at just 30 month old .
Although further work will need to be carried out , the researchers recommend avoid isobutylphenyl propionic acid during those early months .
